CD14+ monocytes are large agranular myeloid-derived leukocytes with roles in the inflammatory and anti-inflammatory processes of the innate immune response. They can differentiate into macrophages and dendritic cells (DC) responsible for phagocytosis, antigen presentation, and cytokine production.
The M1/M2 subtypes of macrophages are key modulators of cancer tumorigenesis. DC-based anti-tumor vaccines are also being explored for cancer immunotherapies. Monocytes are also used in regenerative medicine applications such as wound healing and tissue repair. Their role in the pathology of autoimmune diseases like lupus are providing insight to develop new treatments.
Tissue source: Leukopak
AllCells offers fresh and cryopreserved Monocytes derived from Leukopaks in a variety of types and sizes. The product chart below provides detailed information on standard formats, anticoagulants and unit sizes for Monocytes. Don’t see what you’re looking for? Our Leukopak products can also be Made-to-order (MTO) with custom specifications to meet the specific requirements of your research project. For more information, please visit our MTO page or reach out to our Customer Success Team.
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Monocyte cells isolated from Leukopaks are available through positive or negative immunomagnetic bead separation. Positive immunomagnetic bead separation - beads bind to the target cell population from the heterogenous mixture; labeled target cells remain while the non-target cells are removed. Negative immunomagnetic bead separation - beads bind to the non-target cell population to deplete them from the mixture leaving behind the unlabeled cells of interest.
At AllCells, we believe that your success is our success. We believe that sharing our knowledge and expertise is more than a business practice, it’s a responsibility. And we believe that collaboration leads to better outcomes. Below is a collection of relevant links to Monocytes resouces including blog posts, webinars and useful protocols to help you become more efficient and more effective. Have technical questions about Monocytes products? Our Customer Success Team is standing by.
AllCells offers bulk cell isolations of important cell types from single-donor leukapheresis and bone marrow material—standard and sequential immunomagnetic separation protocols are available. Obtain large quantities of quality-controlled cells including CD34+ HSPCs, lymphocyte populations (T cells, B cells, NK cells, and monocytes), and PBMCs for a variety of research and biomedical applications. Contact us for specific donor requests and custom isolation protocols.
Obtaining bulk quantities of highly pure and viable isolated cells from a qualified vendor offers researchers the opportunity to bank cells to support experimental consistency and comparability, and streamlines laboratory workflows.
AllCells and Discovery Life Sciences advance science in an innovative, collaborative, and client-centric environment. We are grounded in a “Science at your Service” attitude.