CD34+ HSPCs
Hematopoietic stem and progenitor cells (HSPCs) are the key stem cell population in the bone marrow capable of self-renewal and multilineage differentiation into mature blood cell types. CD34+ HSPCs can be isolated from mobilized peripheral blood, bone marrow, and umbilical cord blood.
Clinical HSPC transplantation is used to treat blood cancers (leukemia, myeloma and lymphomas), autoimmune diseases, and more. Gene-modified HSPCs (in vivo or ex vivo) are a promising new modality for a growing number of human diseases including cancer, hemophilia A, beta-thalassemia, and sickle cell disease.
Tissue source: Mobilized Leukopak, Bone Marrow, Cord Blood
Tissue Source
Mobilized Leukopaks, Bone Marrow, Cord Blood
Isolated Cell
Isolated CD34+ HSCs are available from Mobilized Leukopaks, Bone Marrow, or Cord Blood. Positive immunomagnetic separation is used where CD34+ beads bind to target cells in the heterogeneous population - CD34+ cells remain bound to the beads while unwanted cells are removed. All our products are quality controlled for cell count and viability and are determined using a validated AO/PI protocol.
Research & Development Applications
- Fundamental Research (proliferation, biomarker discovery)
- Drug Discovery
- Immuno-oncology
- Cell Therapy process development
At AllCells, we believe that your success is our success. We believe that sharing our knowledge and expertise is more than a business practice, it’s a responsibility. And we believe that collaboration leads to better outcomes. Below is a collection of relevant links to CD34+ resouces including blog posts, webinars and useful protocols to help you become more efficient and more effective. Have technical questions about CD34+ products? Our Customer Success Team is standing by.
WEBINARS
BLOG POSTS
- FAQ Blog Series: What’s the Difference between Positive and Negative Immunomagnetic Cell Separation?
- Dual Mobilization Enhances CD34+ Yield Across All Donor Types
- The Therapeutic Potential of HSC-based Gene Therapies
- FAQ Series: Comparison of CD34+ Cells from Different Tissue Sources
- Clinical Applications of Bone Marrow-Derived Mesenchymal Stem Cells
Bulk Cell Isolation
AllCells offers bulk cell isolations of important cell types from single-donor leukapheresis and bone marrow material—standard and sequential immunomagnetic separation protocols are available. Obtain large quantities of quality-controlled cells including CD34+ HSPCs, lymphocyte populations (T cells, B cells, NK cells, and monocytes), and PBMCs for a variety of research and biomedical applications. Contact us for specific donor requests and custom isolation protocols.
Obtaining bulk quantities of highly pure and viable isolated cells from a qualified vendor offers researchers the opportunity to bank cells to support experimental consistency and comparability, and streamlines laboratory workflows.