Bone marrow is an excellent source of CD34+ hematopoietic stem and progenitor cells (HSPCs) and mesenchymal stem cells. It is the primary site of hematopoiesis in adults, the process of mature blood cell formation from HSPCs to maintain blood homeostasis.
Bone Marrow products are collected by qualified clinicians from the posterior iliac crest of healthy and consenting donors following IRB-approved protocols. Bone Marrow is available in fresh, cryopreserved, or frozen, and in different formats:
AllCells can manufacture the following bone marrow products:
Whole – Whole bone marrow aspirate.
MNC – Mononuclear cells isolated from bone marrow aspirate.
(CUL) MSC – Cultured mesenchymal stem cells derived from adherent nucleated cells from the bone marrow.
(HSC) CD34+ PS – Isolated cells positive for CD34. Phenotypically characteristic hematopoietic stem cells. Isolation by magnetic microbead positive selection.
MNC | CD34 dep – Mononuclear cells that are depleted of CD34 positive cells.
Bone Marrow products are collected by qualified clinicians from the posterior iliac crest of a healthy donor. Aspirate (50mL) is drawn from each hip from a maximum of 2 sites using multiple syringes. The aspirate is filtered to remove clots, bone chips, spicules, and then pooled to normalize cell concentration between draws. Whole Tissue, CD34 Hematopoietic Stem and Progenitor Cells (HSPCs), Mononuclear Cells (PBMCs), Mesenchymal Stromal Cells
*Cell type, cell selection method, and unit size (by volume or cell count) vary depending on format.
AllCells' on-site collection and processing facilities enable us to offer custom, made-to-order (MTO) products to meet the unique needs of our customers. From tissue collection to product shipment, AllCells’ experienced team of experts will help you define, design, and deliver your customized, primary cell material.
We can accommodate specific donor requests, custom bone marrow isolation requirements, additional cell characterization studies and more.LEARN MORE
Bone marrow aspirates and cells are collected from the posterior iliac crest of healthy IRB consenting donors via needle aspiration. Aspirate (50mL) is drawn from each hip from a maximum of 2 sites using multiple syringes containing anticoagulants. The aspirate is then filtered to remove clots, bone chips, spicules, and pooled to normalize cell concentration between draws.
Mononuclear cells (MNCs) from bone marrow are isolated by density gradient separation to remove granulocytes and red blood cells (RBCs) and washed to remove platelets.
CD34+ HSPCs isolated from Bone Marrow in fresh and cryopreserved formats are also available.
All products are quality controlled for cell count and viability determined using a validated AO/PI protocol.
At AllCells, we believe that your success is our success. We believe that sharing our knowledge and expertise is more than a business practice, it’s a responsibility. And we believe that collaboration leads to better outcomes. Below is a collection of relevant links to Mobilized Leukopak resouces including blog posts, webinars and useful protocols to help you become more efficient and more effective. Have technical questions about Mobilized Leukopak products? Our Customer Success Team is standing by.
AllCells offers fresh and cryopreserved Bone Marrow in a variety of container types and sizes. The product chart below provides detailed information on standard formats, anticoagulants and unit sizes for both cellular and non-cellular Bone Marrow. Don’t see what you’re looking for? Our Bone Marrow products can also be Made-to-order (MTO) with custom specifications to meet the specific requirements of your research project. For more information on Bone Marrow MTO, please visit our MTO page or reach out to our Customer Success Team. Need immediate help? Chat with a live agent now.
|Whole||3mL, 10mL, 25mL, 50mL, 100mL||—|
|CD34+ PS||1M, 2M||0.5M, 1M, 2M|
|CD34+ Depleted MNC||100M||100M|