Mobilized Leukopak
Mobilized Leukopaks are apheresis products collected from healthy donors treated with FDA-approved drugs to stimulate the migration of CD34+ hematopoietic stem and progenitor cells (HSPCs) from the bone marrow niche into the circulation. Mobilized peripheral blood, enriched in single-donor CD34+ HSPCs is collected through leukapheresis using the Spectra Optia® Apheresis System’s continuous flow centrifugal technology. The ease of collection and high yield of single-donor CD34+ cells is a major advantage to researchers to gain experimental consistency and scalability.
AllCells is the industry leader in supplying mobilized Leukopaks with the shortest lead time on the market. We have six different mobilization regimens available using G-CSF (Neupogen®), plerixafor (Mozobil®), or a combination of the two drugs as well as CD34+ cells isolated from mobilized Leukopaks.
- Whole Mobilized Apheresis Tissue
- Isolated Cells: CD34+ HSPCs
AllCells can manufacture the following mobilized leukopak products:
Whole – blood bag collected from leukapheresis after mobilization
(HSC) CD34+ PS – Isolated cells positive for CD34. Phenotypically characteristic hematopoietic stem cells. Isolation by magnetic microbead positive selection.
Mobilized Leukopaks are apheresis products collected from healthy donors treated with approved drugs to stimulate mobilization of CD34+ hematopoietic stem and progenitor cells (HSPCs) from the bone marrow to the peripheral blood. This procedure results in large-scale yields of single-donor CD34+ HSPCs, allowing for scalability and reproducibility of experiments by limiting the impact of donor-to-donor variability. AllCells offers Mobilized Leukopaks with different mobilization regimens, including G-CSF (Neupogen®), plerixafor (Mozobil®), or a combination of the two drugs. Mobilized Leukopak products are offered either fresh or cryopreserved, and in different tissue formats*: Whole Mobilized Apheresis Tissue, CD34 Hematopoietic Stem and Progenitor Cells (HSPCs), Multiple Mobilization Regimens Available.
*Cell type, cell selection method, and unit size (by volume or cell count) vary depending on tissue format.
Additional Search Terms: mPB026-Reg.F, mPB018F, mPB015F, mPB016F, mPB017F, mPB009, Mobilized Leukopak
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Mobilized Leukopak Made-to-order
AllCells' on-site collection and processing facilities enables us to offer custom, made-to-order (MTO) products to meet the unique needs of our customers. From tissue collection to product shipment, AllCells’ experienced team of experts will help you define, design, and deliver your customized primary cell material.
We can accommodate specific donor requests, custom mobilization regimens requirements, bulk isolations, cryopreservation needs and more.
LEARN MOREWhole Tissue: Healthy, consenting donors are subcutaneously injected by our qualified clinicians using the following regimen guidelines:
Reg F
Filgrastim (Neupogen) 10ug/kg/day x 5 days, apheresis on day 5 and 6
Reg H
Filgrastim (Neupogen) 10ug/kg/day x 5 days + Mozobil 240ug/kg/day x 2 days on day 4 and 5 (evenings), apheresis on day 5 and 6
Moz Reg A
Plerixafor (Mozobil) 240ug/kg/day x 1 day (evening), apheresis day 2 (morning); 11 hours between injection and collection
Moz Reg C
Plerixafor (Mozobil) 240ug/kg/day x 1 day (morning), apheresis day 1 (afternoon); 6 hours between injection and collection6
Moz Reg B
Plerixafor (Mozobil) 240ug/kg/day x 2 days (evenings), apheresis on day 2 and 3 (mornings); 11 hours between injection and collection
Moz Reg D
Plerixafor (Mozobil) 240ug/kg/day x 2 days (mornings), apheresis day 1 and day 2 (afternoon); 6 hours between injection and collection
Isolated Cells: CD34+ HSPCs isolated from any of the mobilized leukapheresis collections are available. Positive immunomagnetic separation is used where CD34+ beads bind to target cells in the heterogeneous population - CD34+ cells remain bound to the beads while unwanted cells are removed.
At AllCells, we believe that your success is our success. We believe that sharing our knowledge and expertise is more than a business practice, it’s a responsibility. And we believe that collaboration leads to better outcomes. Below is a collection of relevant links to Mobilized Leukopak resouces including blog posts, webinars and useful protocols to help you become more efficient and more effective. Have technical questions about Mobilized Leukopak products? Our Customer Success Team is standing by.
WEBINARS
BLOG POSTS
- Dual Mobilization Enhances CD34+ Yield Across All Donor Types
- The Therapeutic Potential of HSC-based Gene Therapies
- Why You Should Start Clinical Grade Cell Supply Discussions Early in Cell and Gene Therapy Development
- What You Need to Know About Regenerative Medicine in 2022: Industry and Tech Trends
- A Donor-Centric Approach to Cell and Gene Therapy
- FAQ Series: Comparison of CD34+ Cells from Different Tissue Sources