AllCells® Natural Killer (NK) Cells
Natural killer (NK) cells are cytotoxic effectors of the innate immune system with a primary role in immunosurveillance. They are capable of mounting rapid immune responses against foreign pathogens and tumor cells. Primary CD56+ NK cells can be isolated from leukapheresis material (Leukopaks) via positive or negative immunomagnetic separation.
Scientists are working on autologous and allogeneic NK cell-based cancer immunotherapies (i.e., CAR-NK cells) to treat a variety of blood and solid tumor cancers like lymphoma, leukemia, melanoma, and breast cancer.
Tissue source: Leukopaks
NK Cell Formats, Attributes, and Unit Sizes
Discovery offers fresh and cryopreserved NK cells derived from Leukopaks in a variety of types and sizes. The product chart below provides detailed information on standard formats and unit sizes for NK cells. Don’t see what you’re looking for? Our Leukopak products can also be Made-to-order (MTO) with custom specifications to meet the specific requirements of your research project.
| Product | Cryopreserved |
|---|---|
| CD56+ NK, Negative Selection | 5M |
| CD56+ NK, Positive Selection | 5M |
*Bulk isolation services are available from fresh and cryopreserved starting material of full and half leukopaks
For more information, please visit our MTO page or reach out to our Customer Success Team.
Tissue Source
LeukopaksIsolated Cell
NK cells isolated from Leukopaks are available through positive or negative immunomagnetic bead separation. Positive immunomagnetic bead separation – beads bind to the target cell population from the heterogenous mixture; labeled target cells remain while the non-target cells are removed. Negative immunomagnetic bead separation – beads bind to the non-target cell population to deplete them from the mixture leaving behind the unlabeled cells of interest.
Research & Development Applications
- Fundamental Research (Proliferation, Biomarker Discovery)
- CAR-NK Discovery
- Drug Discovery
- Immuno-oncology
- Cell Therapy process development
At Discovery, we believe that your success is our success. We believe that sharing our knowledge and expertise is more than a business practice, it’s a responsibility. And we believe that collaboration leads to better outcomes. Below is a collection of relevant links to Monocytes resouces including blog posts, webinars and useful protocols to help you become more efficient and more effective.
WEBINARS
BLOG POSTS
- FAQ Blog Series: What’s the Difference between Positive and Negative Immunomagnetic Cell Separation?
- Why You Should Start Clinical Grade Cell Supply Discussions Early in Cell and Gene Therapy Development
- FAQ Series: The Science Behind Cryopreservation
- Harnessing the Power of Natural Killer Cells for Cancer Immunotherapy
Have technical questions about Monocytes products? Our Customer Success Team is standing by.
AllCells® Bulk Cell Isolation
Discovery’s AllCells® Bulk Cell Isolation Services cover a wide range of cell types from single-donor leukapheresis and bone marrow material. Obtain large quantities of quality-controlled cells including CD34+ HSPCs, lymphocyte populations (T cells, B cells, NK cells, and monocytes), and PBMCs for a variety of research and biomedical applications. Contact us for specific donor requests and custom isolation protocols.
Obtaining bulk quantities of highly pure and viable isolated cells from a qualified vendor offers researchers the opportunity to bank cells to support experimental consistency and comparability, and streamlines laboratory workflows.
